College football is back! We will be here each and every Monday to give you a first look at the lines for the upcoming weekend — or in this case, five days — of college football. The Week 1 slate is full of fun matchups and games from across the country.

Here are lines for some of the biggest games of the weekend, as well as a few that happened to catch my eye as particularly intriguing. As always, spreads and over/unders are courtesy of our good friends at SportsLine.

Lines you need to know

No. 3 Oklahoma Sooners (-10) at No. 15 Houston Cougars : This could very well be the best game of the weekend, and it kicks off at 11 a.m. local time in Houston. The Sooners are among the national title favorites behind Alabama Crimson Tide and Clemson Tigers but to get there they must get through an incredibly difficult part of the schedule that starts with a very good Houston team that will be looking to prove it wasn’t a one-year wonder in 2015.

No. 1 Alabama (-10.5) vs. No. 20 Southern California Trojans : The prime-time Saturday night game features the reigning national champions against the Trojans in Arlington, Texas, in what will be a battle of new quarterbacks. The Tide are heavy favorites despite an ongoing quarterback controversy, while the Trojans are turning the keys over to Max Browne . Oddsmakers don’t seem too concerned about the turnover on Alabama’s offense to start the year, opening them as double-digit favorites.

No. 18 Georgia Bulldogs (-2.5) vs. No. 22 UNC: The Georgia Dome will give this a home game feel for the Bulldogs in Kirby Smart’s first game as head coach. North Carolina Tar Heels will have a chance to prove last year’s run to the ACC title game was not a fluke against a Georgia team that could be starting a true freshman at quarterback.

No. 11 Ole Miss Rebels (+4.5) vs. No. 4 Florida State Seminoles : The Deondre Francois era begins for the ‘Noles on Monday night in Orlando when they take on Ole Miss in the matchup of highest rated teams of the entire weekend. While they may be starting a new quarterback, the Seminoles return a ton of talent for the 2016 season, while Ole Miss has an opposite feel with Chad Kelly back under center but a lot of turnover around him for the Rebels.

These may raise some eyebrows

No. 10 Notre Dame Fighting Irish (-3.5) at Texas: Notre Dame dominated this game in South Bend last year, and yet, the Irish are only favored by a field goal and the hook as they head to Austin, Texas, on Sunday to take on the Longhorns. This line seems funky, especially with Texas expected to send out a freshman quarterback against a talented Irish defense that is not afraid to try and heat up a quarterback.