ORCHARD PARK, N.Y. – Marcell Darues has been back from suspension for nearly two weeks, but his 2016 debut is in doubt for a second consecutive week thanks to a nagging hamstring injury.

On Friday Bills head coach Rex Ryan revealed the team’s official Week 6 injury report, which listed Dareus as doubtful for Sunday’s meeting with the San Francisco 49ers. Last week, the 26-year-old practiced all week and expected to play in Los Angeles, before suffered a coming up lame on the final day of practice and being held out.

“We were really disappointed because he was having a really good week of practice and then on Friday, he’s chasing E.J. (Manuel), you know, sprinting after E.J., and he pulls a hamstring,” Ryan explained earlier this week. “It was like, “Oh, man!” We were having a great practice and the wind kind of went out of our sails a little bit there. He couldn’t play. It was one of those things where we traveled him to see how he felt. Then we thought it was best not to play him.”

His Week 6 doubtful designation doesn’t come as much of a surprise considering Dareus did not practice the entire week.

“Walking around I feel pretty good, but when I try to get out there a little bit and try to run and get moving I’m sore with some stiffness,” Dareus said of the injury. “If you get out there a little too soon it can re-occur. So you want to make sure it’s treated properly and that it’s ready to go before they let you go.”

As for T Cyrus Kouandjio, who injured his ankle in Week 3, he practiced for the first time on Friday in a limited capacity. He along with eight other Bills players are listed as questionable for Sunday.

Questionable: T Cordy Glenn (ankle), CB Corey White (shoulder), DT Corbin Bryant (ankle), P Colton Schmidt (quad), OL Patrick Lewis (knee), LB Zach Brown (ankle), S Aaron Williams (ankle), TE Charles Clay (knee)

Nobody has been ruled out at this point.

Follow me on Twitter: @Spencito6